BO 4.1 SP 6 and Crystal Reports 2013

I have just applied SP 6 to my test BO 4.1 system. Everything looks good except for the crystal reports 2013 scheduled reports. All of my scheduled Crystal Reports instances are failing in the LaunchPad with the following message: Database Connector Error: 'RFC_INVALID_HANDLE'
These reports ran fine on BO 4.1 SP 5, but when I applied SP 6 they began failing.

Has anyone run into this issue?
 
Thanks,
Nick